home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Arsenal Files 6
/
The Arsenal Files 6 (Arsenal Computer).ISO
/
health
/
med9604b.zip
/
M9640614.TXT
< prev
next >
Wrap
Text File
|
1996-03-04
|
2KB
|
36 lines
Document 0614
DOCN M9640614
TI An unclassified cerebral small cell tumor in a patient with human T-cell
lymphotropic virus type 1-induced primary extranodal lymphoma.
DT 9604
AU Komori T; Kasajima T; Yamamoto T; Shibata N; Kobayashi M; Department of
Pathology, Tokyo Women's Medical College, Japan.
SO Mod Pathol. 1995 Oct;8(8):811-6. Unique Identifier : AIDSLINE
MED/96117029
AB We describe an autopsy case of a thalamic tumor in a patient with human
T-cell lymphotropic virus type 1 (HTLV-1)-induced extranodal lymphoma of
the skull. Neither brain tumors associated with adult T-cell leukemia
nor HTLV-1-induced extranodal lymphoma of bone have previously been
reported. The tumor, which resembled an oligodendroglioma or
dysembryoplastic neuroepithelial tumor, was composed of medium-sized
cells with dark, round-to-polygonal nuclei and a mucinous matrix that
formed pericellular lakes. Tumor cells were immunoreactive with S-100
protein and neuron-specific enolase but not with glial fibrillary acid
protein, synaptophysin, or vimentin. Tumor cells had prominent rough
endoplasmic reticulum and free ribosomes with short processes,
compatible with an oligodendroglial or small neuronal nature. Many
atypical lymphocytes had infiltrated the leptomeningeal space,
subependymal zone along the ventricular walls, fornices, corpus
callosum, and right frontal lobe. Multinucleated or bizarre astrocytes
and macrophages were found exclusively in the right frontal white
matter. The coexistence of this unclassified peculiar brain tumor with
bizarre astrocytosis suggests a cytopathic effect of HTLV-1 on human
glioneuronal cells.
DE Adult Astrocytes/PATHOLOGY Brain Neoplasms/*PATHOLOGY Case Report
Human Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*PATHOLOGY
Male Skull Neoplasms/*PATHOLOGY Thalamus JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).